Thermo Fisher Scientific PRPF18 Polyclonal Antibody
PRPF18 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 ICC/IF에 사용 가능. Human, Mouse, Rat에서 반응하며, Affinity chromatography로 정제됨. PBS/glycerol buffer에 보관되며, -20°C에서 안정적 저장 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PRPF18 (Accession Q99633), corresponding to amino acid residues D181–R231 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851206 |
Product Specific Information
Antibody detects endogenous levels of total PRPF18.
Target Information
PRPF18 (pre-mRNA-splicing factor 18), also known as HPRP18, is a 342 amino acid protein localized to nuclear speckles and involved in the second step of pre-mRNA splicing. It belongs to the PRP18 family, contains seven WD repeats, and exists as two alternatively spliced isoforms encoded by a gene located on human chromosome 10p13. Chromosome 10 includes over 800 genes and 135 million nucleotides. PTEN, an important tumor suppressor gene on chromosome 10, is associated with Cowden syndrome when defective. Other disorders linked to chromosome 10 include Cockayne syndrome, tetrahydrobiopterin deficiency, and trisomy 10.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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