Thermo Fisher Scientific Nogo-B Polyclonal Antibody
Thermo Fisher Scientific의 Nogo-B Polyclonal Antibody는 인간 및 생쥐에 반응하며 Western blot과 IHC(P) 분석에 적합합니다. CHO 유래 재조합 인간 Nogo-B 항원을 면역원으로 사용한 비결합 양 IgG 항체입니다. 항원 친화 크로마토그래피로 정제되었으며, 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–15 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CHO-derived recombinant human Nogo-B (Met1–Val200) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2577080 |
Product Specific Information
- In direct ELISAs, less than 1% cross-reactivity with recombinant human Nogo-A and recombinant rat Nogo-A is observed.
- Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
NogoA is a member of the reticulon protein family, integral membrane proteins involved in various cellular processes and neurodegenerative diseases. Reticulons interact with multiple proteins and receptors such as BACE. NogoA was first identified as a myelin-associated neurite outgrowth inhibitor and is highly expressed in oligodendrocytes in CNS white matter. Blocking NogoA activity enhances axon regrowth and functional recovery in CNS lesion models. Elevated NogoA levels have been observed in neurodegenerative diseases such as Amyotrophic lateral sclerosis and multiple sclerosis, where autoantibodies to NogoA are found in serum and cerebrospinal fluid.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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