Thermo Fisher Scientific VAMP2 Polyclonal Antibody
VAMP2 단백질을 인식하는 Thermo Fisher Scientific의 Sheep Polyclonal Antibody. WB 및 IHC에 사용 가능하며 Human, Mouse, Rat에 반응. Lyophilized 형태로 제공되며 장기 보관 시 -20°C 권장. 연구용으로만 사용 가능.
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- OSV00009G-500UG
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Thermo Fisher Scientific VAMP2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 10–50 µg/mL |
| Immunohistochemistry (IHC) | 10–50 µg/mL |
| Miscellaneous PubMed (Misc) | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from human VAMP2 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
- The peptide is homologous in many other species including rat, mouse, and xenopus.
- Specificity: VAMP2.
Target Information
The vesicle associated membrane proteins (VAMP) or synaptobrevins are calcium-binding proteins specific to eukaryotes. VAMPs, along with synaptosomal associated protein of 25 kDa (SNAP-25) and syntaxin, form the core complex of soluble NSF attachment protein receptor (SNARE) proteins that interact with soluble proteins N-ethylmaleimide-sensitive factor (NSF) and alpha-SNAP. These membrane-associated proteins play a key role in vesicle membrane fusion regulation with the plasma membrane.
Clostridium tetani neurotoxin acts as a metalloprotease specific for VAMP. In Alzheimer’s disease, VAMP levels of all isoforms appear significantly lowered. It is suggested that VAMP2 is a resident protein of the insulin-sensitive glucose transporter type 4 (GLUT4) compartment and is required for GLUT4 vesicle incorporation into the cell surface in response to insulin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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