Thermo Fisher Scientific VAMP2 Polyclonal Antibody
VAMP2 단백질을 인식하는 Thermo Fisher Scientific의 양친화성 항체로, 인간·마우스·랫트 시료에 반응합니다. WB 및 IHC에 사용 가능하며, 합성 펩타이드 면역원으로 제작된 비결합 항체입니다. 신경세포 소포 융합 연구에 적합합니다.
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Thermo Fisher Scientific VAMP2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | – |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | – |
| Miscellaneous PubMed (Misc) | – | View 3 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Sheep / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from human Vesicle-associated membrane protein 2 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The peptide is homologous in many species including rat, mouse, and xenopus.
- Specificity: VAMP2.
Target Information
The vesicle-associated membrane proteins (VAMP), also known as synaptobrevins, are calcium-binding proteins specific to eukaryotes.
VAMPs, together with SNAP-25 and syntaxin, form the core SNARE complex that interacts with NSF and alpha-SNAP, playing a key role in vesicle membrane fusion with the plasma membrane.
- Neurotoxin interaction: Clostridium tetani neurotoxin specifically targets VAMP.
- Disease relevance: VAMP levels are reduced in Alzheimer’s disease.
- Functional role: VAMP2 is a resident protein of the insulin-sensitive GLUT4 compartment, required for vesicle incorporation into the cell surface in response to insulin.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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