Thermo Fisher Scientific PATZ1 Monoclonal Antibody (OTI2D2), TrueMAB

Thermo Fisher Scientific PATZ1 Monoclonal Antibody (OTI2D2), TrueMAB

Applications

• Western Blot (WB): 1:500–1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

The PATZ1 protein contains an A-T hook DNA binding motif that interacts with other DNA-binding structures, playing a key role in chromatin modeling and transcription regulation.
Its POZ domain mediates protein-protein interactions necessary for transcriptional repression, while zinc-finger regions form the DNA-binding domain.
In small round cell sarcoma, PATZ1 can fuse with EWS due to a chromosomal inversion on 22q, leading to a chimeric sequence combining the EWS transactivation domain with the PATZ1 zinc-finger domain.
Four alternatively spliced transcript variants are known for this gene.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.

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