Thermo Fisher Scientific CRACC Polyclonal Antibody
Human SLAMF7(CD319) 인식하는 Rabbit Polyclonal Antibody로 Western blot에 최적화됨. KLH 결합 합성 펩타이드(58–85 aa)로 면역화. Protein A 및 항원 친화 크로마토그래피로 정제됨. 액상 형태, 0.5 mg/mL 농도, PBS buffer 및 sodium azide 포함.
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Applications
- Western Blot (WB)
Tested Dilution: 1:1,000
Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 58–85 amino acids from the central region of human SLAMF7 (CRACC, CD319, UniProt ID: Q9NQ25-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2543089 |
Target Information
SLAMF7 contains one Ig-like C2-type (immunoglobulin-like) domain.
Isoform 1 mediates NK cell activation through a SAP-independent ERK-mediated pathway and may play a role in lymphocyte adhesion.
Isoform 3 does not mediate activation. SAP can bind the cytoplasmic tail of isoform 1 when phosphorylated in the presence of Fyn (in vitro).
SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung, and trachea.
Expression detected in NK cells, activated B-cells, and NK-cell line but not in promyelocytic, B-, or T-cell lines.
Isoform 3 is expressed at a much lower level than isoform 1.
There are three named isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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