Thermo Fisher Scientific WRN Recombinant Rabbit Monoclonal Antibody (JE52-72)
Recombinant rabbit monoclonal antibody recognizing human WRN protein. Validated for Western blot at 1:1,000 dilution. Expressed in HEK293 cells and purified via Protein A. Supplied in TBS buffer with BSA and glycerol. Suitable for research use only.
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Applications
- Western Blot (WB): Tested dilution 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JE52-72 |
| Immunogen | Recombinant protein within Human WRN aa 1,260–1,432 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 0.05% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2890369 |
Target Information
The WRN gene encodes a member of the RecQ and DEAH subfamilies of DNA and RNA helicases. These enzymes are essential in DNA metabolism, including transcription, replication, recombination, and repair. The WRN protein contains a nuclear localization signal at the C-terminus and predominantly localizes to the nucleolus. It exhibits 3’ to 5’ DNA helicase and exonuclease activities. Interaction with the Ku70/80 heterodimer suggests a role in double-strand DNA break repair. Mutations in WRN cause Werner syndrome, an autosomal recessive disorder characterized by premature aging.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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