Thermo Fisher Scientific ATXN1L Polyclonal Antibody
Rabbit polyclonal antibody recognizing human ATXN1L protein. Validated for ICC/IF applications. Supplied as liquid, unconjugated form with 0.1 mg/mL concentration. Suitable for research use in studying chromatin-binding and Notch signaling pathways.
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Applications
- Immunocytochemistry (ICC/IF): 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human ATXN1L. Recombinant protein control fragment (Product #RP-107176) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2662504 |
Product Specific Information
Immunogen sequence:
AHSFNKAPSAT SPSGQLPHHS STQPLDLAPG RMPIYYQMSR LPAGYTLHET PPAGASPVLT PQESQS
Highest antigen sequence identity to the following orthologs:
- Mouse: 87%
- Rat: 84%
Target Information
Chromatin-binding factor that represses Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and may assist, along with NCOR2, in RBPJ-mediated repression (PubMed:21475249). Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, it is involved in brain development. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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