Thermo Fisher Scientific KappaB ras1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human KappaB ras1 for ICC/IF applications. Recombinant NKIRAS1 immunogen, antigen affinity purified, unconjugated liquid form. High specificity and cross-reactivity with mouse and rat orthologs. For research use only.
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Thermo Fisher Scientific KappaB ras1 Polyclonal Antibody
Applications
- Immunocytochemistry (ICC/IF)
Tested dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human NKIRAS1. Recombinant protein control fragment (Product #RP-107172) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2664985 |
Product Specific Information
Immunogen sequence:KEQLHLYDTRG LQEGVELPKH YFSFAD
Highest antigen sequence identity to the following orthologs:
- Mouse: 96%
- Rat: 100%
Target Information
KappaB ras-1 (kappa-B-ras-1) and kappaB-ras-2 are small Ras-like GTPases that associate with Ikappa-B (inhibitor of NF-kappa-B).
Ikappa-B exists in two homologous forms, Ikappa-B-alpha and Ikappa-B-beta, with Ikappa-B-beta containing a unique 47-amino acid region within its ankyrin domain.
Inactive Ikappa-B-alpha–NF-kappa-B complexes can shuttle between nucleus and cytoplasm, whereas Ikappa-B-beta–NF-kappa-B complexes remain cytoplasmic.
KappaB-ras proteins preferentially bind to Ikappa-B-beta through this unique insert, modulating its cellular localization and degradation rate.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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