Thermo Fisher Scientific Phospho-SCNN1B (Ser633) Polyclonal Antibody
Phospho-SCNN1B (Ser633) 폴리클로날 항체로, 인간·마우스·랫트 시료에 반응합니다. Western blot, IHC, ICC, ELISA 등 다양한 응용에 사용 가능하며, Protein A로 정제된 1 mg/mL 액상 항체입니다. -20°C에서 보관하며 연구용으로만 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from human SCNN1B around Ser633 phosphorylation site |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01 M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates electrodiffusion of luminal sodium (and water) through the apical membrane of epithelial cells. Controls sodium reabsorption in kidney, colon, lung, and sweat glands, and also plays a role in taste perception. The channel is a heterotetramer of two alpha, one beta, and one gamma subunit, with a delta subunit potentially replacing alpha. It interacts with the WW domains of NEDD4, NEDD4L, WWP1, and WWP2.
Defects in SCNN1B are associated with:
- Pseudohypoaldosteronism type 1 (PHA1): A rare salt-wasting disease due to mineralocorticoid unresponsiveness, presenting in neonates with dehydration, hyponatremia, hyperkalemia, and metabolic acidosis.
- Liddle Syndrome: An autosomal dominant disorder characterized by pseudoaldosteronism and hypertension with hypokalemic alkalosis, caused by constitutive activation of the renal epithelial sodium channel.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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