Thermo Fisher Scientific CX3CR1 Recombinant Rabbit Monoclonal Antibody (1H14L7)
CX3CR1 단백질을 인식하는 재조합 토끼 모노클로날 항체로, WB, IHC, ICC/IF에 사용 가능. 높은 특이성과 민감도, 로트 간 일관성 제공. 인간, 생쥐, 랫드 반응성 확인. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | - |
| Immunohistochemistry (IHC) | - | View 2 publications |
| Immunocytochemistry (ICC/IF) | 2 µg/mL | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 1H14L7 |
| Immunogen | Peptides corresponding to human CX3CR1 (aa6–19, 339–351) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2662897 |
Product Specific Information
This antibody is predicted to react with Monkey, Dog, and Cat.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The DNA sequences from immunoreactive rabbits are cloned, and individual clones are screened for optimal production.
Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
Target Information
CX3CR1 is a chemokine receptor required as a coreceptor for HIV infection. Human, mouse, and rat CX3CR1 genes were cloned and designated V28, CMKBRL1, CX3CR1, and RBS11, respectively.
The encoded seven-transmembrane protein acts as a receptor for fractalkine and mediates leukocyte migration and adhesion. CX3CR1 is expressed in various human tissues and cell lines.
CX3CR1 also serves as a coreceptor for HIV-1 and HIV-2 envelope fusion and infection, which can be inhibited by fractalkine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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