Thermo Fisher Scientific KIT Monoclonal Antibody (OTI6F8), TrueMAB

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:150

Product Specifications

Target Information

KIT (c-KIT) is a proto-oncogene and a type 3 transmembrane receptor for mast cell growth factor (MGF, also known as stem cell factor, SCF). It was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT and its ligand regulate the growth and activation of various hematopoietic and non-hematopoietic cells.

Mutations in KIT are associated with:

• Gastrointestinal stromal tumors (GIST)
• Mast cell disease
• Acute myelogenous leukemia (AML)
• Piebaldism

Deregulation of KIT receptor tyrosine kinase, particularly the D816V mutation, is a key target in therapeutic strategies for neoplastic mast cell growth. c-Kit is expressed in hematopoietic stem cells, germ cells, mast cells, and gastrointestinal tract Cajal cells. Upon SCF binding, c-Kit dimerizes and undergoes autophosphorylation on tyrosine residues such as Tyr703, enabling Grb2 docking and activation of the Ras/ERK pathway. SCF/c-Kit signaling also activates PI3K, PLC-γ, and JAK/STAT pathways, which are essential for hematopoiesis, stem cell maintenance, and gametogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.