Thermo Fisher Scientific KIT Monoclonal Antibody (OTI6F8), TrueMAB
인간 c-Kit(CD117)을 인식하는 단클론 항체로 IHC(P)에서 검증됨. E.coli에서 생산된 인간 재조합 단백질(aa 27-308)을 면역원으로 사용. 1 mg/mL 농도의 액상 제품으로, PBS/1% BSA/50% glycerol에 보관. 연구용으로만 사용 가능.
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- TA808746
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- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6F8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 27–308 of human KIT produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
KIT (c-KIT) is a proto-oncogene and a type 3 transmembrane receptor for mast cell growth factor (MGF, also known as stem cell factor, SCF). It was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT and its ligand regulate the growth and activation of various hematopoietic and non-hematopoietic cells.
Mutations in KIT are associated with:
- Gastrointestinal stromal tumors (GIST)
- Mast cell disease
- Acute myelogenous leukemia (AML)
- Piebaldism
Deregulation of KIT receptor tyrosine kinase, particularly the D816V mutation, is a key target in therapeutic strategies for neoplastic mast cell growth. c-Kit is expressed in hematopoietic stem cells, germ cells, mast cells, and gastrointestinal tract Cajal cells. Upon SCF binding, c-Kit dimerizes and undergoes autophosphorylation on tyrosine residues such as Tyr703, enabling Grb2 docking and activation of the Ras/ERK pathway. SCF/c-Kit signaling also activates PI3K, PLC-γ, and JAK/STAT pathways, which are essential for hematopoiesis, stem cell maintenance, and gametogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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