Thermo Fisher Scientific KAL1 Monoclonal Antibody (OTI5E10), TrueMAB
인간 KAL1 단백질(아노스민-1)을 인식하는 Mouse IgG2a 단일클론 항체로, IHC(P) 실험에 적합. 1 mg/mL 농도의 액상 형태이며, PBS/BSA/글리세롤 버퍼에 보존. 칼만 증후군 관련 연구용으로 사용 가능.
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Applications
Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5E10 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 129–373 of human KAL1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
KAL1 (Anosmin-1) is an extracellular matrix-associated glycosylated protein linked to Kallmann Syndrome (KS), an X-linked genetic disorder characterized by anosmia (loss of smell) and delayed puberty due to abnormal olfactory bulb development and disrupted migration of gonadotropin-releasing hormone neurons.
Anosmin-1 binds FGFR1 via its N-terminal cysteine-rich domain, whey-acidic protein-like domain, and first FnIII repeat with the D2 and D3 ectodomains of FGFR1. It is suggested that Anosmin-1 modulates FGFR1 signaling and influences the formation and activation of the FGF2–FGFR1–heparin complex.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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