Thermo Fisher Scientific TEM5 Polyclonal Antibody
TEM5 단백질을 인식하는 Rabbit Polyclonal Antibody로, 인간 조직에서 높은 특이성을 보임. IHC(P) 등 다양한 응용에 적합하며, 항원 친화 크로마토그래피로 정제됨. 액상 형태로 1 mg/mL 농도, 4°C 또는 -20°C 보관 권장.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 2–5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 19 amino acid peptide from N-terminal extracellular domain of human GPR124 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550997 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- Human, Gibbon: 100%
- Monkey, Marmoset, Elephant: 95%
- Gorilla, Dog, Panda: 89%
- Bat, Hamster, Horse, Pig: 84%
Target Information
Tumor endothelial markers (TEMs) are significantly up-regulated during angiogenesis and neoangiogenesis, which are crucial for solid tumor growth. TEMs localized on the cell surface and conserved across species are of particular interest for developing anti-angiogenic therapies.
TEM5 is a member of the adhesion family of G protein-coupled receptors and is localized on the surface of endothelial cells. It is a seven-pass transmembrane receptor, unlike TEM1, TEM7, and TEM8 which span the membrane once. TEM5 is abundantly expressed in tumor vessels, heart, placenta, ovary, small intestine, and colon. Proteolytically processed soluble TEM5 mediates endothelial cell survival during angiogenesis by linking integrin to glycosaminoglycans.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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