Thermo Fisher Scientific CD123 Monoclonal Antibody (6H6), PE-Cyanine7, eBioscience
인간 CD123 (IL-3 수용체 α사슬)을 인식하는 6H6 클론 단일클론 항체로, PE-Cyanine7 형광체가 결합되어 있습니다. 유세포분석(Flow Cytometry)에 최적화되어 있으며, 광민감성이 있어 암실 보관이 필요합니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific CD123 Monoclonal Antibody (6H6), PE-Cyanine7, eBioscience™
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | - | View 2 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | - | View 2 publications |
| Flow Cytometry (Flow) | 5 µL (1 µg)/test | View 20 publications |
Product Specifications
| Item | Specification |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse, Non-human primate, Rhesus monkey |
| Host/Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE-Cyanine7, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6H6 |
| Conjugate | PE-Cyanine7 |
| Excitation/Emission Max | 569/780 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1257136 |
Available Formats:
- Unconjugated
- Alexa Fluor 532
- Alexa Fluor 700
- APC
- APC-eFluor 780
- Biotin
- Brilliant UV 395
- Brilliant UV 615
- Brilliant UV 661
- Brilliant UV 737
- Brilliant UV 805
- Brilliant Violet 480
- Brilliant Violet 786
- eFluor 450
- FITC
- NovaFluor Blue 510
- PE
- PE-Cyanine5
- PE-eFluor 610
- PerCP-Cyanine5.5
- Super Bright 436
- Super Bright 600
- Super Bright 645
- Super Bright 702
- Request custom conjugation
Product Specific Information
The 6H6 monoclonal antibody reacts with human CD123, the alpha chain of the IL-3 receptor (60–70 kDa transmembrane protein). CD123 binds IL-3 with low affinity alone, and with CD131 forms a high-affinity IL-3 receptor complex. It is expressed by myeloid precursors, macrophages, dendritic cells, mast cells, basophils, and megakaryocytes.
Applications Reported: Flow cytometric analysis.
Applications Tested: Pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. Use at 5 µL (1 µg) per test (100 µL final volume). Cell number range: 10⁵–10⁸ cells/test.
Light Sensitivity: Protect from light; tandem dye is photo-sensitive.
Fixation: Samples can be stored up to 3 days in the dark at 4°C using IC Fixation Buffer (Product #00-8222-49) or 1-step Fix/Lyse Solution (Product #00-5333-54) with minimal brightness impact.
Excitation/Emission: 488–561 nm / 775 nm; compatible with Blue, Green, and Yellow-Green lasers.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
IL-3Ra (Interleukin-3 receptor subunit alpha)
Belongs to the type I cytokine receptor family. Forms a heterodimer with the common beta chain (CDw131). Responsible for IL-3 signal transduction. IL-3Ra/IL-3Rb heterodimerization is induced by IL-3 and required for receptor activation. Overexpressed in acute myeloid leukemia (AML) blasts compared to normal hematopoietic cells, making it a potential therapeutic target.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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