Thermo Fisher Scientific Phospho-KV4.2 (KCND2) (Ser616) Polyclonal Antibody
Phospho-KV4.2 (Ser616) 폴리클로날 항체로, 인산화된 KCND2 단백질을 특이적으로 검출합니다. Western blot과 IHC(P) 실험에 적합하며, 사람, 생쥐, 랫드 시료에 반응합니다. 고순도 정제 및 안정적인 PBS/glycerol buffer로 제공됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human KCND2 (Accession Q9NZV8), corresponding to amino acid residues around phosphorylated Ser616. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817211 |
Product Specific Information
This antibody detects endogenous levels of Kv4.2/KCND2 only when phosphorylated at Ser616.
Target Information
Voltage-gated potassium (Kv) channels are a complex class of ion channels involved in regulating diverse physiological processes such as neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume.
Four sequence-related potassium channel genes—shaker, shaw, shab, and shal—were first identified in Drosophila, and each has human homologs.
The KCND2 gene encodes a member of the voltage-gated, shal-related potassium channel subfamily, forming voltage-activated A-type potassium ion channels prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current, not controlled by the N terminus as in Shaker channels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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