Thermo Fisher Scientific CDK4 Polyclonal Antibody
Rabbit polyclonal antibody against human CDK4, validated for WB, IHC, IHC(P), and IP. Targets residues 253–303 of CDK4. Supplied as 1 mg/mL liquid, unconjugated form. Recommended storage at 4°C. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 253 to 303 of human Cyclin-Dependent Kinase 4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
Target Information
CDK4/cyclin D3 serine/threonine kinase is a dimeric protein complex. CDK4, a member of the cyclin-dependent protein kinase family, regulates cell proliferation during the G1 phase of the cell cycle. It forms a complex with D-type cyclins and is inhibited by p16 (cyclin-dependent kinase inhibitor-2). CDK4 mediates phosphorylation of the C-terminal region of Rb protein, leading to transcriptional repression of the E2F complex. CDC37 and HSP90 preferentially associate with CDK4 not bound to D-type cyclins. SMAD3 is a major physiological substrate of CDK4 and CDK2. While both CDK6 and CDK4 phosphorylate multiple residues in Rb protein, they differ in residue selectivity in vitro: CDK6 phosphorylates Thr821, whereas CDK4 phosphorylates Thr826.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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