Thermo Fisher Scientific SARS-CoV-2 Neutralizing Monoclonal Antibody (6D11F2)
SARS-CoV-2 스파이크 단백질 RBD를 표적으로 하는 중화 단일클론 항체로, ELISA·Flow Cytometry·Neutralization 실험에 적합합니다. 마우스 IgG1, kappa 형식이며 액상 형태로 제공됩니다. COVID-19 관련 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Flow Cytometry (Flow) | 10 µg/mL | - |
| ELISA (ELISA) | 0.01–0.1 µg/mL | - |
| Neutralization (Neu) | 2–10 µg/mL | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Published species | Not Applicable |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6D11F2 |
| Immunogen | Recombinant SARS-CoV-2 Spike protein fragment |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
Product Specific Information
SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2), also known as 2019-nCoV, is a positive-sense single-stranded RNA virus that caused coronavirus disease 2019 (COVID-19).
SARS-CoV-2 contains a glycosylated spike (S) protein composed of S1 and S2 subunits. The S1 subunit includes a receptor-binding domain (RBD) that binds to the ACE2 receptor on target cells.
Target Information
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), also known as 2019-nCoV, causes illnesses ranging from mild cold-like symptoms to severe respiratory distress.
The Spike (S) protein plays a key role in viral attachment, fusion, and entry, serving as a target for antibody and vaccine development.
The receptor-binding domain (RBD, S-RBD) in the Spike protein binds strongly to human and bat ACE2 receptors, exhibiting higher affinity than SARS-CoV RBD.
SARS-CoV-2 S protein is 1273 amino acids long, consisting of:
- Signal peptide (1–13 aa)
- S1 subunit (14–685 aa)
- S2 subunit (686–1273 aa)
The S-ECD represents the extracellular domain of the Spike protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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