Thermo Fisher Scientific MAP4K3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total MAP4K3 protein.

Target Information

MAP4K3 (also known as GLK) is a member of the STE20 family of serine/threonine protein kinases containing an N-terminal catalytic domain and a C-terminal regulatory domain. It acts upstream of MEKK1 and is stimulated by UV radiation and TNF-alpha, leading to activation of the JNK signaling pathway. MAP4K3 can directly activate PKC-T during TCR signaling, and elevated MAP4K3 expression has been observed in T cells from individuals with systemic lupus erythematosus. It functions as a pro-apoptotic kinase, orchestrating activation of BAX via modulation of PUMA, BAD, and BIM. The kinase activity can be stimulated by UV radiation and TNF-alpha, specifically activating the c-Jun N-terminal kinase (JNK) pathway. MAP4K3 was previously referred to as RAB8-interacting protein-like 1 (RAB8IPL1) but has been renamed mitogen-activated protein kinase kinase kinase 3 (MAP4K3).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.