Thermo Fisher Scientific Nephrin Monoclonal Antibody (C8)

Thermo Fisher Scientific Nephrin Monoclonal Antibody (C8)

Applications and Tested Dilution

Product Specifications

Target Information

Primary steroid resistant nephrotic syndrome (SRNS) is characterized by childhood onset of proteinuria and progression to end-stage renal disease. Kidney podocytes and their slit diaphragms form the final barrier to urinary protein loss. Congenital nephrotic syndrome (CNS) is caused by mutations in NPHS1 (nephrin) or NPHS2.
Nephrin, a recently identified protein, is a member of podocyte proteins that constitute a major component of the slit diaphragm, especially in the foot process. As a cell adhesion molecule, Nephrin may play a crucial role in maintaining the glomerular filtration barrier. Mutations in the Nephrin gene can lead to congenital nephrosis.
Three podocyte proteins—Podocin, Nephrin, and alpha Actinin 4—have been identified in congenital and experimental models of proteinuria. Nephrin is believed to be associated with anti-apoptotic activity in podocyte slit diaphragms and VEGF signaling. It plays an important role in the development and function of the kidney glomerular filtration barrier, anchoring the slit diaphragm to the actin cytoskeleton.

Usage Notice

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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