Thermo Fisher Scientific USP16 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 4–6 µg/mL

Product Specifications

Product Specific Information

• Recognizes isoform a (NP_006438.1) and isoform b (NP_001001992.1)
• Tested in Peptide ELISA with antibody detection limit dilution 1:32,000

Target Information

Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26S proteasome are coupled to multiple copies of ubiquitin. Attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity.
Deubiquitination is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families:

1. Ubiquitin C-terminal hydrolases
2. Ubiquitin-specific processing proteases (USPs)
3. OTU-domain ubiquitin-aldehyde-binding proteins
4. Jab1/Pad1/MPN-domain-containing metallo-enzymes

Among these, USPs are the most widespread and conserved across evolution, functioning to release ubiquitin from conjugated proteins. They share conserved catalytic domains (Cys and His boxes) with variable N- or C-terminal extensions, contributing to substrate recognition, localization, and interactions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.