Thermo Fisher Scientific NCF2 Polyclonal Antibody
Human NCF2 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 및 ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS와 글리세롤 완충액에 보관. NADPH oxidase 활성 연구 및 만성 육아종성 질환 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human NCF2. Recombinant protein control fragment (Product # RP-95407) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2644515 |
Product Specific Information
Immunogen sequence:
MLYYQTEKYD LAIKDLKEAL IQLRGNQLID YKILGLQFKL FACEVLYNIA FMYAKKEEWK KAEEQLALAT SMKSEPRHSK IDKAMECVWK QKLYEPVVIP VGRLFRPNER QVAQLAKKDY LGKATVVASV VDQDSFSGFA PLQPQAA
Sequence identity:
- Mouse: 92%
- Rat: 39%
Target Information
NCF2, NCF1, and a membrane-bound cytochrome b558 are required for activation of the latent NADPH oxidase, which is necessary for superoxide production.
Defects in NCF2 cause chronic granulomatous disease (autosomal recessive cytochrome-b-positive type 2, CGD2).
This disease is characterized by the inability of neutrophils and phagocytes to kill ingested microbes, leading to life-threatening bacterial and fungal infections.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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