Thermo Fisher Scientific Calumenin Polyclonal Antibody
Human Calumenin을 인식하는 Rabbit Polyclonal Antibody로 Western blot, IHC, ICC/IF에 적합. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human Calumenin (Product #RP-102171) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2639252 |
Product Specific Information
Immunogen sequence:
TKEEFTAFLH PEEYDYMKDI VVQETMEDID KNADGFIDLE EYIGDMYSHD GNTDEPEWVK TEREQFVEFR DKNRDGKMDK EETKDWILPS DYDHAEAEAR HLVYESDQNK DGKLTKEEIV DKYD
Highest antigen sequence identity to the following orthologs:
- Mouse: 99%
- Rat: 98%
Target Information
Calumenin is a 315 amino acid Ca²⁺-binding member of the CREC, EF-hand protein family. It is a secreted protein located in the lumen of the endoplasmic reticulum (ER) and Golgi apparatus, containing six Ca²⁺-binding (EF-hand) motifs. In the presence of Ca²⁺, Calumenin interacts with serum amyloid P component (SAP) and may contribute to immunological defense and amyloidosis. It has an inhibitory effect on the vitamin K-dependent γ-carboxylation system, and may play a role in thrombosis and wound healing through autocrine or paracrine mechanisms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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