Thermo Fisher Scientific CD357 (AITR/GITR) Polyclonal Antibody
Human GITR/TNFRSF18 단백질을 인식하는 Goat 폴리클로날 항체로, Western blot, IHC, Flow cytometry 및 Neutralization에 적합. 항원 친화 크로마토그래피로 정제되었으며, 보존제가 없는 PBS/trehalose 용액 형태로 제공. 연구용으로만 사용 가능.
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Thermo Fisher Scientific CD357 (AITR/GITR) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–15 µg/mL |
| Flow Cytometry (Flow) | 2.5 µg per million cells |
| Neutralization (Neu) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human GITR/TNFRSF18 (Gln26–Glu161, Thr45Ala) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No preservative |
| Storage Conditions | -20 °C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2576305 |
Product Specific Information
- In direct ELISAs and Western blots, less than 5% cross-reactivity with recombinant mouse GITR and recombinant human 4-1BB is observed.
- Reconstitute at 0.2 mg/mL in sterile PBS.
- Endotoxin level is <0.10 EU per 1 µg of the antibody (LAL method).
Target Information
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also known as GITR or AITR, is a protein encoded by the TNFRSF18 gene in humans, mapped to 1p36.33.
This receptor is part of the TNF-receptor superfamily and shows increased expression upon T-cell activation. It plays a key role in maintaining immunological self-tolerance through CD25(+)CD4(+) regulatory T cells.
Knockout studies in mice indicate its involvement in the regulation of CD3-driven T-cell activation and programmed cell death.
Three alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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