Thermo Fisher Scientific CD357 (AITR/GITR) Polyclonal Antibody

Thermo Fisher Scientific CD357 (AITR/GITR) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• In direct ELISAs and Western blots, less than 5% cross-reactivity with recombinant mouse GITR and recombinant human 4-1BB is observed.
• Reconstitute at 0.2 mg/mL in sterile PBS.
• Endotoxin level is <0.10 EU per 1 µg of the antibody (LAL method).

Target Information

Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also known as GITR or AITR, is a protein encoded by the TNFRSF18 gene in humans, mapped to 1p36.33.
This receptor is part of the TNF-receptor superfamily and shows increased expression upon T-cell activation. It plays a key role in maintaining immunological self-tolerance through CD25(+)CD4(+) regulatory T cells.
Knockout studies in mice indicate its involvement in the regulation of CD3-driven T-cell activation and programmed cell death.
Three alternatively spliced transcript variants encoding distinct isoforms have been reported.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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