Thermo Fisher Scientific APP Monoclonal Antibody (OTI2B10), TrueMAB
인간 APP 단백질을 인식하는 마우스 단클론 항체로, WB, IHC, ICC/IF에 적합합니다. 동결건조 형태이며, 재구성 후 1 mg/mL 농도로 사용 가능합니다. Alzheimer 연구 등 APP 관련 연구용으로 최적화된 고품질 TrueMAB 항체입니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2B10 |
| Immunogen | Full length human recombinant protein of human APP produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Amyloid Precursor Protein (APP) is a transmembrane glycoprotein (100–140 kDa) functioning as a cell surface kinesin I receptor, mediating axonal transport of beta-secretase and presenilin 1. It plays roles in neurite growth, neuronal adhesion, and axonogenesis.
Proteolytic cleavage of APP by beta- and gamma-secretases generates beta amyloid, the primary component of senile plaques—key histopathologic features of Alzheimer’s disease.
Abnormal APP processing is also implicated in Down’s syndrome, familial early-onset Alzheimer’s disease, and cerebral hemorrhage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(해당 항체의 항원 구조 이미지 및 APP 관련 시각 자료가 포함됩니다.)
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