Thermo Fisher Scientific DTYMK Monoclonal Antibody (OTI1E12), TrueMAB
Human DTYMK 단백질을 인식하는 마우스 단클론 항체로 Western blot에 적합합니다. 동결건조 형태로 제공되며, 재구성 시 약 1 mg/mL 농도 권장. DNA 합성 관련 효소 연구 및 항암제 메커니즘 분석에 활용 가능합니다.
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Applications
- Western Blot (WB): 1:2,000 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1E12 |
| Immunogen | Full length human recombinant DTYMK protein produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, it is recommended to perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Thymidylate kinase (DTYMK) catalyzes the phosphorylation of dTMP to form dTDP in the dTTP synthesis pathway essential for DNA synthesis.
DTYMK plays a key role in the metabolism of pyrimidine analog drugs such as 5-Fluorouracil (5-FU), a chemotherapeutic agent used for several solid tumors.
The human DTYMK gene was identified through functional complementation of a Saccharomyces cerevisiae cell cycle mutant (cdc8).
DTYMK mRNA levels and enzyme activity are regulated by cell cycle and growth pathways.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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