Thermo Fisher Scientific MASP2 Monoclonal Antibody (F3-4)
Human MASP2 단백질을 인식하는 Mouse monoclonal antibody(F3-4). Western blot에 적합하며, 단백질 정제는 Protein A 방식으로 수행됨. PBS buffer(40% glycerol, 0.2% BSA)로 보존되어 장기 안정성 우수. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): 1:2,000–1:5,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | F3-4 |
| Immunogen | Synthetic peptide within human MASP2 (aa 335–379) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2911713 |
Product Specific Information
- Positive Control: Human serum
- Subcellular Location: Secreted
Target Information
Mannose (or mannan)-binding lectin (MBL), also known as serum mannose-binding protein (MBP), initiates the lectin branch of the innate immune response by binding to the surface of pathogenic microorganisms and triggering complement fixation through an N-terminal collagen-like domain.
MBL plays a central role in immune defense by enabling antibody-independent neutralization of invading microbes. Mutations in human MBL are linked to immunodeficiency due to impaired complement activation.
In humans, MBL-associated serine proteases (MASP-1, MASP-2, MASP-3) and a truncated form of MASP-2 (sMAP or MAp19) form complexes with MBL to activate the lectin pathway of the complement system. Activated MASPs cleave downstream complement components. MASP-3, an alternatively spliced product of the MASP-1 gene, may inhibit MASP-2 by competing for MBL binding, thereby modulating complement activation.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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