Thermo Fisher Scientific ATM Monoclonal Antibody (2C1)
ATM 단백질을 인식하는 Mouse IgG1 단일클론 항체로, WB, IHC, ICC/IF, IP 등 다양한 응용 가능. 인간, 마우스, 원숭이, 랫트 반응성. 액상 형태로 보존제 없음. DNA 손상 복구 및 세포주기 조절 연구에 적합.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific ATM Monoclonal Antibody (2C1)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:100 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:250–1:500 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2C1 |
| Immunogen | Recombinant protein expressed in E. coli corresponding to amino acids 2577–3056 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Tissue culture supernatant |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787223 |
Product Specific Information
- Keep as concentrated solution.
- Positive Control: Raji and lymphoblastoid nuclear lysate.
- Centrifuge briefly prior to opening the vial.
Target Information
Ataxia-telangiectasia Mutated (ATM) is a protein belonging to the PI3/PI4 kinase family.
Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and increased risk of lymphoid cancer.
The ATM gene encodes a protein in the phosphoinositide 3-kinase (PI3K) superfamily. ATM phosphorylates proteins rather than lipids and regulates cell-cycle proteins such as P53, Mdm2, BRCA1, and SMC1.
ATM repairs double-stranded DNA breaks caused by ionizing radiation and other mutagens. Its C-terminal region shares homology with PI3 kinase catalytic domains.
ATM becomes autophosphorylated and activated upon exposure to ionizing radiation, initiating kinase cascades that regulate cell cycle, apoptosis, and DNA damage repair.
ATM is also linked to apoptosis with Nbs1 and Chk2 in the E2F1 pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.