Thermo Fisher Scientific ATM Monoclonal Antibody (2C1)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Positive Control: Raji and lymphoblastoid nuclear lysate.
• Centrifuge briefly prior to opening the vial.

Target Information

Ataxia-telangiectasia Mutated (ATM) is a protein belonging to the PI3/PI4 kinase family.
Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and increased risk of lymphoid cancer.
The ATM gene encodes a protein in the phosphoinositide 3-kinase (PI3K) superfamily. ATM phosphorylates proteins rather than lipids and regulates cell-cycle proteins such as P53, Mdm2, BRCA1, and SMC1.
ATM repairs double-stranded DNA breaks caused by ionizing radiation and other mutagens. Its C-terminal region shares homology with PI3 kinase catalytic domains.
ATM becomes autophosphorylated and activated upon exposure to ionizing radiation, initiating kinase cascades that regulate cell cycle, apoptosis, and DNA damage repair.
ATM is also linked to apoptosis with Nbs1 and Chk2 in the E2F1 pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.