Thermo Fisher Scientific CLCN4 Polyclonal Antibody
Human CLCN4 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P)에서 1:200–1:500 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol 완충액에 보존. 근육 및 신경 세포 염소 이온 채널 연구에 적합.
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Applications and Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CLCN4. Recombinant protein control fragment (Product # RP-95429) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2639856 |
Product Specific Information
Immunogen sequence:
VVSRDSERLI GFAQRRELIL AIKNARQRQE GIVSNSIMYF TEEPPELPAN SPHPLKLRRI LNLS
Highest antigen sequence identity to orthologs:
- Mouse: 98%
- Rat: 100%
Target Information
Voltage-dependent chloride channels (CLCs) regulate the cellular trafficking of chloride ions, essential for maintaining excitability in muscle and nerve cells, organic solute transport, and cellular volume.
Human CLC genes (CLC-1 to CLC-7) map to chromosomes 7, 3q26, 4q32, Xp22, Xp11, 1p36, and 16p13, respectively.
- CLC-1: Highly expressed in skeletal muscle; mutations linked to myotonia and renal salt wasting.
- CLC-2: Expressed in epithelial tissues (e.g., lung); potential therapeutic target for cystic fibrosis.
- CLC-3: Abundant in neuronal tissue.
- CLC-4: Expressed in skeletal and cardiac muscle as well as brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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