Thermo Fisher Scientific Calumenin Polyclonal Antibody
Rabbit polyclonal antibody against human Calumenin for ICC/IF applications. Recognizes recombinant PrEST antigen sequence (aa 74–128). High purity via affinity chromatography. Supplied in PBS with 40% glycerol, 0.02% sodium azide. For research use only.
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Applications
Immunocytochemistry (ICC/IF)
- Tested dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence (aa 74–128). Recombinant protein control fragment: RP-109870 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3091785 |
Product Specific Information
Immunogen sequence:
GKIVSKIDGD KDGFVTVDEL KDWIKFAQKR WIYEDVERQW KGHDLNEDGL VSWEE
Antigen sequence identity:
- Mouse: 95%
- Rat: 95%
Target Information
Calumenin is a 315 amino acid Ca²⁺-binding member of the CREC, EF-hand protein family. It is a secreted protein containing six Ca²⁺-binding (EF-hand) motifs and is expressed in the lumen of the endoplasmic reticulum (ER) and Golgi apparatus. In the presence of Ca²⁺, Calumenin interacts with serum amyloid P component (SAP), potentially playing a role in immunological defense and amyloidosis. It inhibits the vitamin K-dependent γ-carboxylation system, which converts vitamin K-dependent proteins to Gla-containing proteins, and may be involved in thrombosis and wound healing through autocrine or paracrine mechanisms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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