Thermo Fisher Scientific KCNQ1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human KCNQ1 protein. Validated for ICC/IF applications with high specificity. Supplied as a liquid, unconjugated form at 0.5 mg/mL. Suitable for research on voltage-gated potassium channels and cardiac electrophysio...
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- PA5144998
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Applications
Immunocytochemistry (ICC/IF)
- Tested dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence (range: 545–604). Recombinant protein control fragment (Product #RP-110230) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3091979 |
Product Specific Information
- Immunogen sequence:
YSQGHLNLMV RIKELQRRLD QSIGKPSLFI SVSEKSKDRG SNTIGARLNR VEDKVTQLDQ - Antigen sequence identity:
Mouse 97%; Rat 97%
Target Information
Voltage-gated K⁺ channels in the plasma membrane control repolarization and the frequency of action potentials in neurons, muscles, and other excitable cells. The KCNQ1 alpha subunit, in combination with the KCNE1 beta subunit, is predominantly expressed in the heart and cochlea, regulating the slow, depolarization-activated potassium current.
Mutations in KCNQ1 and KCNE1 genes are linked to cardiac diseases due to impaired electrical signaling, while KCNQ4 mutations are associated with deafness.
KCNQ proteins, including KCNQ1 and KCNQ4, have six transmembrane domains and function as tetramers. KCNQ4 forms heteromeric channels with KCNQ3 and is expressed in several tissues, including cochlear outer hair cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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