Thermo Fisher Scientific MMP13 Monoclonal Antibody (OTI2A6), TrueMAB
인간 MMP13 단백질을 인식하는 Mouse IgG2a 단일클론 항체로 Western blot, IHC, ICC/IF에 사용 가능. TrueMAB 형식으로 높은 특이성과 재현성을 제공하며, 액상 형태로 -20°C 보관. 연구용으로 세포외기질 단백질 분해 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:4,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2A6 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 104–471 of human MMP13 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
MMP13 (collagenase 3) plays a key role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC, and ACAN.
It cleaves triple helical collagens such as type I, II, and III, showing the highest activity with soluble type II collagen.
Additionally, MMP13 can degrade collagen types IV, XIV, and X.
It is involved in wound healing, tissue remodeling, cartilage degradation, bone development, mineralization, and ossification.
MMP13 is required for normal embryonic bone development and ossification.
Mutations in this gene can lead to spondyloepimetaphyseal dysplasia Missouri type, metaphyseal anadysplasia 1, and metaphyseal dysplasia Sphar type.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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