Thermo Fisher Scientific EXOSC7 Monoclonal Antibody (OTI2F5), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

EXOSC7 is a non-catalytic component of the RNA exosome complex with 3'→5' exoribonuclease activity, involved in RNA processing and degradation.
In the nucleus, it contributes to maturation of rRNA, snRNA, and snoRNA, removal of RNA processing by-products, and elimination of aberrant transcripts such as antisense RNA and PROMPTs.
In the cytoplasm, it participates in mRNA turnover and degradation of unstable mRNAs containing AU-rich elements (AREs).
EXOSC7 may also play roles in Ig class switch recombination (CSR) and somatic hypermutation (SHM) by targeting AICDA activity.
The RNA exosome core complex (Exo-9) acts as a scaffold for catalytic and accessory components.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.