Thermo Fisher Scientific ZEB1/2 Polyclonal Antibody
ZEB1/2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, Flow cytometry, ELISA에 사용 가능. Human, Mouse, Rat에 반응하며, Protein A로 정제된 액상 형태. -20°C 보관, 연구용 전용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Flow Cytometry (Flow) | 1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human ZEB1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
ZEB1 inhibits interleukin-2 (IL-2) gene expression and may be responsible for transcriptional repression of the IL-2 gene. It can enhance or repress the promoter activity of the ATP1A1 gene depending on cDNA quantity and cell type.
ZEB1 represses the E-cadherin promoter and induces epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. It also represses BCL6 transcription in the presence of the corepressor CTBP1 and promotes tumorigenicity by repressing stemness-inhibiting microRNAs.
ZEB2 is a transcriptional inhibitor that binds to the DNA sequence 5'-CACCT-3' in different promoters and represses transcription of E-cadherin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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