Thermo Fisher Scientific MTM1 Polyclonal Antibody, MaxPab

Applications

• Western Blot (WB)
  Tested Dilution: 1:500–1:1,000

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MASASTSKYN SHSLENESIK RTSRDGVNRD LTEAVPRLPG ETLITDKEVI YICPFNGPIK GRVYITNYRL YLRSLETDSS LILDVPLGVI SRIEKMGGAT SRGENSYGLD ITCKDMRNLR FALKQEGHSR RDMFEILTRY AFPLAHSLPL FAFLNEEKFN VDGWTVYNPV EEYRRQGLPN HHWRITFINK CYELCDTYPA LLVVPYRASD DDLRRVATFR SRNRIPVLSW IHPENKTVIV RCSQPLVGMS GKRNKDDEKY LDVIRETNKQ ISKLTIYDAR PSVNAVANKA TGGGYESDDA YHNAELFFLD IHNIHVMRES LKKVKDIVYP NVEESHWLSS LESTHWLEHI KLVLTGAIQV ADKVSSGKSS VLVHCSDGWD RTAQLTSLAM LMLDSFYRSI EGFEILVQKK WISFGHKFAS RIGHGDKNHT DADRSPIFLQ FIDCVWQMSK QFPTAFEFNE QFLIIILDHL YSCRFGTFLF NCESARERQK VTERTVSLWS LINSNKEKFK NPFYTKEINR VLYPVASMRH LELWVNYYIR WNPRIKQQQP NPVEQRYMEL LALRDEYIKR LEELQLANSA KLSDPPTSPS SPSQMMPHVQ THF

Target Information

Human MTM1 is a 603 amino-acid protein mutated in myotubular myopathy. The related protein hMTMR2 is mutated in Charcot-Marie-Tooth neuropathy. Myotubularin acts as a lipid phosphatase on phosphatidylinositol 3-monophosphate and regulates the PI 3-kinase pathway and membrane trafficking. Wild-type myotubularin can dephosphorylate PI 3-P and PI 4-P in vitro, reducing PI 3-P levels by down-regulating PI 3-K activity and promoting PI 3-P degradation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.