Thermo Fisher Scientific MTM1 Polyclonal Antibody, MaxPab
MTM1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, Western blot에 적합합니다. Human 및 Mouse 반응성을 가지며 PBS 버퍼에 보존되어 있습니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | MTM1 (AAH30779.1, 1–603 a.a.) full-length human protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MASASTSKYN SHSLENESIK RTSRDGVNRD LTEAVPRLPG ETLITDKEVI YICPFNGPIK GRVYITNYRL YLRSLETDSS LILDVPLGVI SRIEKMGGAT SRGENSYGLD ITCKDMRNLR FALKQEGHSR RDMFEILTRY AFPLAHSLPL FAFLNEEKFN VDGWTVYNPV EEYRRQGLPN HHWRITFINK CYELCDTYPA LLVVPYRASD DDLRRVATFR SRNRIPVLSW IHPENKTVIV RCSQPLVGMS GKRNKDDEKY LDVIRETNKQ ISKLTIYDAR PSVNAVANKA TGGGYESDDA YHNAELFFLD IHNIHVMRES LKKVKDIVYP NVEESHWLSS LESTHWLEHI KLVLTGAIQV ADKVSSGKSS VLVHCSDGWD RTAQLTSLAM LMLDSFYRSI EGFEILVQKK WISFGHKFAS RIGHGDKNHT DADRSPIFLQ FIDCVWQMSK QFPTAFEFNE QFLIIILDHL YSCRFGTFLF NCESARERQK VTERTVSLWS LINSNKEKFK NPFYTKEINR VLYPVASMRH LELWVNYYIR WNPRIKQQQP NPVEQRYMEL LALRDEYIKR LEELQLANSA KLSDPPTSPS SPSQMMPHVQ THF
Target Information
Human MTM1 is a 603 amino-acid protein mutated in myotubular myopathy. The related protein hMTMR2 is mutated in Charcot-Marie-Tooth neuropathy. Myotubularin acts as a lipid phosphatase on phosphatidylinositol 3-monophosphate and regulates the PI 3-kinase pathway and membrane trafficking. Wild-type myotubularin can dephosphorylate PI 3-P and PI 4-P in vitro, reducing PI 3-P levels by down-regulating PI 3-K activity and promoting PI 3-P degradation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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