Thermo Fisher Scientific MUC4 Monoclonal Antibody (5B12)
인체 MUC4 단백질을 인식하는 Mouse IgG2a 단클론 항체로, Western blot, IHC, ELISA 등에 사용 가능. Affinity chromatography로 정제된 액상 형태이며, PBS(pH 7.4) buffer에 보존제 없이 제공. 암 및 점막 관련 질환 연구에 유용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-Dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5B12 |
| Immunogen | MUC4 (NP_004523, 79 a.a. approximately 188 a.a) partial recombinant protein with GST tag (MW of GST tag = 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
GVSLFPYGAD AGDLEFVRRT VDFTSPLFKP ATGFPLGSSL RDSLYFTDNG QIIFPESDYQ IFSYPNPLPT GFTGRDPVAL VAPFWDDADF STGRGTTFYQ EYETFYGEHS
Target Information
Nearly all mucosal surfaces are protected by mucin transmembrane glycoproteins, from bronchioles to corneas to reproductive tracts.
Mucin 4 (MUC4) is membrane-bound and plays a key role in protection and lubrication.
MUC4 expression is abnormal in various carcinomas and sarcomas, including fibromyoxoid sarcoma and pancreatic adenocarcinoma.
Immunohistochemical staining for MUC4 has been proposed as a potential biomarker for cancer detection.
MUC4 abnormalities are linked to diseases such as Taiwanese infertility, endometriosis, and gallstone formation in Chinese men.
Due to its role in mucosal surface protection, MUC4 dysfunction is implicated in many metastatic cancer invasions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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