Thermo Fisher Scientific FBXO32 Polyclonal Antibody, MaxPab

Thermo Fisher Scientific FBXO32 Polyclonal Antibody, MaxPab

Applications and Tested Dilution

• Western Blot (WB): 1:500–1:1,000

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MPFLGQDWRS PGQNWVKTAD GWKRFLDEKS GSFVSDLSSY CNKEVYNKEN LFNSLNYDVA AKKRKKDMLN SKTKTQYFHQ EKWIYVHKGS TKERHGYCTL GEAFNRLDFS TAILDSRRFN YVVRLLELIA KSQLTSLSGI AQKNFMNILE KVVLKVLEDQ QNIRLIRELL QTLYTSLCTL VQRVGKSVLV GNINMWVYRM ETILHWQQQL NNIQITRPAF KGLTFTDLPL CLQLNIMQRL SDGRDLVSLG QAAPDLHVLS EDRLLWKKLC QYHFSERQIR KRLILSDKGQ LDWKKMYFKL VRCYPRKEQY GDTLQLCKHC HILSWKGTDH PCTANNPESC SVSLSPQDFI NLFKF

Target Information

This gene encodes a member of the F-box protein family characterized by an approximately 40 amino acid motif, the F-box. These proteins form subunits of the ubiquitin ligase complex (SCFs), functioning in phosphorylation-dependent ubiquitination.
F-box proteins are classified into three types:

1. Fbws: containing WD-40 domains
2. Fbls: containing leucine-rich repeats
3. Fbxs: containing diverse interaction modules or no recognizable motifs

FBXO32 belongs to the Fbxs class and includes an F-box domain. It is highly expressed during muscle atrophy, and deficiency in mice confers resistance to atrophy. Thus, FBXO32 is a potential therapeutic target for muscle atrophy. Alternative splicing yields two transcript variants encoding isoforms of different sizes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.