Thermo Fisher Scientific CD38 Monoclonal Antibody (38C03 (SPC32))

Applications and Tested Dilutions

Product Specifications

Product Specific Information

MA5-14413 targets CD38 in WB, FACS, and IHC (P) applications and shows reactivity with human and mouse samples.
This antibody is not suitable for Jurkat cell lysates or mouse thymus tissues in Western blot analysis.
The MA5-14413 immunogen is a recombinant protein encoding the extracellular domain of human CD38.

Target Information

CD38 (NAD⁺ glycohydrolase) is a type II transmembrane glycoprotein that induces activation, proliferation, and differentiation of mature lymphocytes and mediates apoptosis of myeloid and lymphoid progenitor cells.
It functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase, and possibly NAD⁺ glycohydrolase, or as a cell surface receptor.

Antibodies to CD38 are useful for:

• Subtyping lymphomas and leukemias
• Detection of plasma cells (e.g., identification of myelomas)
• Marker for activated B and T cells

CD38 participates in cell adhesion, signal transduction, and calcium signaling.
It is expressed at high levels in the pancreas, liver, kidney, malignant lymphoma, and neuroblastoma.
Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter’s Syndrome.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.