Thermo Fisher Scientific Npr2 Polyclonal Antibody
인간 및 생쥐 NPR2 단백질을 검출하는 Rabbit Polyclonal Antibody. IHC(P)에서 1:50~1:200 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제된 고품질 항체. PBS/glycerol 버퍼에 0.9 mg/mL 농도로 제공되며 -20°C 보관. 연구용으로만 사용.
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Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region derived from internal residues of human natriuretic peptide receptor 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.9 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2636166 |
Product Specific Information
This antibody detects endogenous levels of total NPR2 protein.
Target Information
This gene encodes natriuretic peptide receptor B (NPR2), one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains:
- Extracellular ligand-binding domain
- Single membrane-spanning region
- Intracellular protein kinase homology domain
- Helical hinge region involved in oligomerization
- Carboxyl-terminal guanylyl cyclase catalytic domain
The NPR2 protein acts as the primary receptor for C-type natriuretic peptide, which upon ligand binding shows greatly increased guanylyl cyclase activity. Mutations in this gene are associated with acromesomelic dysplasia Maroteaux type.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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