Thermo Fisher Scientific Activin A Polyclonal Antibody
Activin A 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot, IHC, ICC/IF에 적합. 인간, 마우스, 랫트 반응성. 1 mg/mL 액상 형태로 제공되며, 친화 크로마토그래피로 정제됨. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within human Inhibin beta A (aa 340–390/426) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | TBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2913480 |
Product Specific Information
- Positive Control: SW1990 cell lysate, PANC-1 cell lysate, mouse colon tissue lysate, rat liver tissue lysate, rat heart tissue lysate, SiHa, human placenta tissue, mouse placenta tissue.
- Subcellular Location: Secreted.
Target Information
Activins are dimeric growth and differentiation factors belonging to the transforming growth factor-beta (TGF-beta) superfamily. They signal through a heteromeric complex of receptor serine kinases including type I (I and IB) and type II (II and IIB) receptors. These receptors are transmembrane proteins with extracellular ligand-binding domains, a transmembrane domain, and a cytoplasmic domain with serine/threonine kinase activity. Type I receptors are essential for signaling, while type II receptors are required for ligand binding and type I receptor expression. Ligand binding induces formation of a stable complex and phosphorylation of type I receptors by type II receptors. Mutations in Activin A are associated with fibrodysplasia ossificans progressiva.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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