Thermo Fisher Scientific Human GM-CSF, Animal-Free Recombinant Protein, PeproTech

Applications

ELISA

• Tested Dilution: Not specified
• Publications: View 2 publications

Functional Assay

• Assay-dependent
• Publications: View publications

In vitro Assay

• Tested Dilution: Not specified
• Publications: View 93 publications

Miscellaneous PubMed

• Tested Dilution: Not specified
• Publications: View 1 publication

Product Specifications

Product Specific Information

Recombinant Human GM-CSF is a 14.6 kDa globular protein consisting of 128 amino acids containing two intramolecular disulfide bonds and two potential N-linked glycosylation sites.
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.

Target Information

The GM-CSF gene encodes a cytokine that regulates the production, differentiation, and function of macrophages and granulocytes. The active protein exists as a homodimer in the extracellular space.
This gene is located in the chromosome region 5q31, associated with interstitial deletions in 5q- syndrome and acute myelogenous leukemia. Other genes in this cluster include interleukins 4, 5, and 13.
It plays a role in promoting tissue inflammation. Elevated cytokine levels, including GM-CSF, have been observed in SARS-CoV-2 infected patients with acute respiratory distress syndrome.
Mice lacking this gene or its receptor develop pulmonary alveolar proteinosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.