Thermo Fisher Scientific p38 MAPK Recombinant Rabbit Monoclonal Antibody (ARC0201)
Recombinant Rabbit Monoclonal Antibody for p38 MAPK detection. Validated for WB and ELISA. High specificity to human, mouse, and rat. Purified by affinity chromatography, supplied in liquid form. Ideal for research on stress and inflammation signaling ...
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- MA535577
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:2,000
ELISA
- Tested Concentration: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC0201 |
| Immunogen | Synthetic peptide corresponding to amino acids 100–200 of human p38 MAPK (UniProt ID: Q16539) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.62 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849477 |
Product Specific Information
Immunogen sequence:
NDVYLVTHLM GADLNNIVKC QKLTDDHVQF LIYQILRGLK YIHSADIIHR DLKPSNLAVN EDCELKILDF GLARHTDDEM TGYVATRWYR APEIMLNWMH Y
Target Information
The p38 MAPK cascade regulates various cellular responses to stress, inflammation, and other stimuli. p38 MAPK is inactive in its nonphosphorylated form and becomes rapidly activated by dual phosphorylation of the Thr-Gly-Tyr motif. There are four isoforms of p38 MAPK, differing in tissue expression and interactions with upstream activators and downstream effectors. Upon exposure to tumor necrosis factor, interleukin-1, or heat shock, MAPK kinase-3/6 phosphorylates Thr180 and Tyr182 residues in p38 MAPK. Phospho-p38 MAPK subsequently activates transcription factors such as ATF-2, CHOP-1, and MEF-2 through phosphorylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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