Thermo Fisher Scientific SMURF1 Polyclonal Antibody
SMURF1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot에 적합하며 인간 및 생쥐 반응성. 액상 형태로 1 mg/mL 농도, PBS와 50% glycerol 저장 버퍼 포함. -20°C에서 보관.
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Applications
- Western Blot (WB): Tested dilution 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SMURF1 (Accession Q9HCE7), corresponding to amino acid residues C174–P224 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900569 |
Product Specific Information
Antibody detects endogenous levels of total SMURF1.
Target Information
Members of the transforming growth factor-beta (TGFB) family signal through type I and type II serine/threonine-kinase receptors, which activate the SMAD signaling pathway.
Bone morphogenetic protein (BMP) receptors target SMAD1, SMAD5, and SMAD8, whereas activin and TGFB receptors (e.g., ACVR1 and TGFBR1) target SMAD2 and SMAD3.
Phosphorylation of these receptor-regulated SMADs induces their association with SMAD4.
Smurf1, a HECT domain E3 ubiquitin ligase, regulates cell polarity and protrusive activity and is required to maintain tumor cell morphology and motility.
PKCζ, an effector of the Cdc42/Rac1-PAR6 polarity complex, recruits Smurf1 to cellular protrusions, controlling local RhoA levels.
Smurf1 links the polarity complex to RhoA degradation in lamellipodia and filopodia, preventing RhoA signaling during dynamic membrane movements.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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