Thermo Fisher Scientific Phospho-YAP1 (Ser127) Polyclonal Antibody
YAP1 단백질의 Ser127 인산화 상태를 검출하는 Rabbit Polyclonal 항체. Western blot, ICC, IP 등에 사용 가능. Human, Mouse, Rat 시료에 반응하며 항원 친화 크로마토그래피로 정제됨. 연구용으로만 사용.
- 카탈로그번호
- PA517481
- 판매단위
- pk
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Thermo Fisher Scientific Phospho-YAP1 (Ser127) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 5 publications |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| Immunoprecipitation (IP) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pSer127 of human YAP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 59.2 µg/mL |
| Purification | Antigen affinity chromatography, Protein A |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10981511 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
YAP (Yes-Associated Protein) is a founding member of the WW domain family of proteins, acting as a transcriptional co-activator and oncogene. The YAP gene is transcriptionally activated in squamous cell carcinoma cells. YAP functions as both a coactivator and corepressor and serves as a critical downstream target in the Hippo signaling pathway, which regulates organ size and tumor suppression by controlling proliferation and promoting apoptosis. YAP also plays key roles in tissue tension, 3D tissue shape, cell proliferation, cell death, and cell migration. Mutations in the IRF5 gene can result in coloboma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: PA5-17481_YAP1_P46937-1_Rabbit.svg, PA5-17481_YAP1_P46937-1_Rabbit_PDP.jpeg)
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