Thermo Fisher Scientific SWAP70 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Positive Control: Jurkat, Raji, NCI-H929, 293T, A431, HeLa, HepG2
• Predicted Reactivity: Rat (95%), Chicken (89%), Rhesus Monkey (99%), Bovine (93%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

SWAP70 is a 585 amino acid regulatory protein belonging to the pleckstrin-like family with a PH domain essential for phosphatidylinositol 3,4,5-trisphosphate binding.
It acts as a link between the recognition of specific switch regions and causation of DNA breaks and is involved in both nuclear events and B-cell activation signaling.
As a guanine nucleotide exchange factor (GEF), SWAP70 transduces signals from tyrosine kinase receptors to RAC, independent of RAS.
It mediates membrane ruffling and actin cytoskeleton signaling, and is expressed in most tissues, mature B-cells, monocytes, and macrophages.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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