Thermo Fisher Scientific SWAP70 Polyclonal Antibody
SWAP70 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 사용 가능. 인간 및 마우스 반응성, 항원 친화 크로마토그래피로 정제. 액상 형태, 4°C 또는 -20°C 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:5,000–1:20,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the C-terminus region of human SWAP70. The exact sequence is proprietary. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2736669 |
Product Specific Information
- Positive Control: Jurkat, Raji, NCI-H929, 293T, A431, HeLa, HepG2
- Predicted Reactivity: Rat (95%), Chicken (89%), Rhesus Monkey (99%), Bovine (93%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
SWAP70 is a 585 amino acid regulatory protein belonging to the pleckstrin-like family with a PH domain essential for phosphatidylinositol 3,4,5-trisphosphate binding.
It acts as a link between the recognition of specific switch regions and causation of DNA breaks and is involved in both nuclear events and B-cell activation signaling.
As a guanine nucleotide exchange factor (GEF), SWAP70 transduces signals from tyrosine kinase receptors to RAC, independent of RAS.
It mediates membrane ruffling and actin cytoskeleton signaling, and is expressed in most tissues, mature B-cells, monocytes, and macrophages.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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