Thermo Fisher Scientific PEAR1 Polyclonal Antibody
PEAR1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. WB 및 IHC에 사용 가능하며, 인간, 마우스, 랫트 반응성. 액상 형태로 1 mg/mL 농도, 항원 친화 크로마토그래피로 정제. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (IHC) | 2.5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 16 amino acid peptide near the carboxy terminus of human PEAR1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11151873 |
Product Specific Information
- Suggested positive control: rat kidney tissue lysate
- PA5-21057 can be used with blocking peptide PEP-1171
Target Information
Platelet endothelial aggregation receptor 1 (PEAR1) is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation. Upon platelet aggregation stimulated by physiological agonists, PEAR1 becomes tyrosine- and serine-phosphorylated; the tyrosine phosphorylation can be inhibited by eptifibatide, an αIIbβ3 antagonist that also inhibits platelet aggregation.
Recent studies have indicated that genetic variations in PEAR1 may be associated with enhanced agonist-induced platelet aggregation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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