Thermo Fisher Scientific HOXA11 Polyclonal Antibody
HOXA11 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC에 적합합니다. Human 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS(40% glycerol) 용액 형태로 제공되며, 단기 4°C, 장기 -20°C 보관이 권장됩니다.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific HOXA11 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Cat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human HOXA11. Recombinant protein control fragment (Product # RP-96536) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642519 |
Product Specific Information
Immunogen sequence:
EVTFREYAIE PATKWHPRGN LAHCYSAEEL VHRDCLQAPS AAGVPGDVLA KSSANVYHHP TPAVSSNFY
Antigen sequence identity:
- Mouse: 100%
- Rat: 100%
Target Information
HOX11 (also called homeobox11 or Tcl-3) is located at the 10q24 T-cell translocation breakpoint region. It encodes a homeobox-domain containing protein with a glycine and proline-rich amino terminus. HOX11 is required for maintenance of the developing spleen and cell survival. The HOX11 protein binds to a specific DNA sequence and localizes to the cell nucleus, acting as a transcription activator. The HOX11 gene is highly expressed in T-ALLs due to chromosomal translocations such as t(7;10)(q35;q24) or t(10;14)(q24;q11), leading to deregulation and activation of tumor-associated target genes. HOX11 gene translocation is associated with T-cell leukemia and lymphoid neoplasias.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.