Thermo Fisher Scientific F4/80 Polyclonal Antibody
Rabbit Polyclonal Antibody targeting Human EMR1 (F4/80) for Western Blot applications. Preservative-free formulation with protein A and antigen affinity purification. Suitable for macrophage marker studies. Store at 4°C short term or -20°C long term.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the center region of Human EMR1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787647 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human EMR1.
Target Information
F4/80 antigen is a 160 kDa cell surface glycoprotein belonging to the EGF-TM7 family of proteins. It shares 68% overall amino acid identity with human EGF module-containing mucin-like hormone receptor 1 (EMR1). Expression of F4/80 varies during macrophage maturation and activation and is found on a wide range of mature tissue macrophages including Kupffer cells, Langerhans cells, microglia, and macrophages in the gut lamina propria, peritoneal cavity, lung, thymus, bone marrow stroma, and red pulp of the spleen.
F4/80 expression has also been reported on a subpopulation of dendritic cells but is absent in macrophages located in T cell areas of the spleen and lymph node. The ligands and biological functions of the F4/80 antigen are not fully determined, but studies suggest a role in the generation of efferent CD8⁺ regulatory T cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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