Thermo Fisher Scientific F4/80 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human EMR1.

Target Information

F4/80 antigen is a 160 kDa cell surface glycoprotein belonging to the EGF-TM7 family of proteins. It shares 68% overall amino acid identity with human EGF module-containing mucin-like hormone receptor 1 (EMR1). Expression of F4/80 varies during macrophage maturation and activation and is found on a wide range of mature tissue macrophages including Kupffer cells, Langerhans cells, microglia, and macrophages in the gut lamina propria, peritoneal cavity, lung, thymus, bone marrow stroma, and red pulp of the spleen.
F4/80 expression has also been reported on a subpopulation of dendritic cells but is absent in macrophages located in T cell areas of the spleen and lymph node. The ligands and biological functions of the F4/80 antigen are not fully determined, but studies suggest a role in the generation of efferent CD8⁺ regulatory T cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.