Thermo Fisher Scientific SIGLEC7 Monoclonal Antibody (OTI1E3), TrueMAB
인간 SIGLEC7 단백질을 인식하는 마우스 단클론 항체로, Western blot에 최적화됨. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공. PBS, BSA, 글리세롤 버퍼에 안정화되어 -20°C 보관. 세포 접착 및 면역 반응 연구용.
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Applications
- Western Blot (WB): Tested dilution 1:4,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1E3 |
| Immunogen | Full length human recombinant protein of human SIGLEC7 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide).
The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand-induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) that block signal transduction through dephosphorylation of signaling molecules.
Mediates inhibition of natural killer cell cytotoxicity and may play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic lineage and proliferation of leukemic myeloid cells (in vitro).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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