Thermo Fisher Scientific ARHGEF7 Polyclonal Antibody
Human ARHGEF7 단백질에 특이적인 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 0.2 mg/mL 농도의 액상 형태로 제공됩니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific ARHGEF7 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ARHGEF7. Recombinant protein control fragment (Product #RP-88620) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2638181 |
Product Specific Information
Immunogen sequence:
RMSGFIYQGK LPTTGMTITK LEDSENHRNA FEISGSMIER ILVSCNNQQD LQEWVEHLQK QTKVTSVGNP TIKPHSVPSH TLPSHPVTPS SKHADSKPAP LTPAYHTLPH PSHHGTPHTT INWGPLEPPK TPKPW
Ortholog sequence identity:
- Mouse: 94%
- Rat: 95%
Target Information
The serine/threonine kinase, p21 activated kinase (PAK), is a downstream effector of the small GTPases Cdc42 and Rac. PAK associates with Nck, the p85 and p110 subunits of PI3-kinase and PIX (PAK-interacting exchange factor) in a focal complex. The binding of PIX is necessary for the localization and activation of PAK in the Cdc42 to Rac signaling pathway, and this binding occurs through the high affinity of the N-terminal SH3 domain of PIX for a conserved proline rich PAK sequence. PIX exists as two isoforms, alpha and beta, and both are highly expressed in heart, muscle and thymus tissues of human and rat. alphaPIX is phosphorylated via PDGF and EphB2 receptor signaling pathways or through association with PI3-kinase. The alphaPIX isoform predominantly acts as a guanine nucleotide exchange factor (GEF) on Rac, which may mediate lamellipodia formation.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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